12H-Benzo[g]pyrido[2,1-b]quinazoline-4-carboxamide, N-[2-(dimethylamino)ethyl]-12-oxo-

Name	BMH-21
Synonyms	BMH21 BMH-21 BMH 21 CS-1749 N-[2-(Dimethylamino)ethyl]-12-oxo-2H-benzo[g]pyrido[2,1-b]quinazoline-4-carboxamide N-[2-(dimethylamino)ethyl]-12-oxo-12H-benzo[g]pyrido[2,1-b]quinazoline-4-carboxamide 12H-Benzo[g]pyrido[2,1-b]quinazoline-4-carboxamide, N-[2-(dimethylamino)ethyl]-12-oxo- BMH-21 N-[2-(Dimethylamino)ethyl]-12-oxo-12H-benzo[g]pyrido[2,1-b]quinazoline-4-carboxamide
CAS	896705-16-1
EINECS	809-833-1

Molecular Formula	C21H20N4O2
Molar Mass	360.41
Solubility	10 mM in DMSO
Appearance	powder
Color	light yellow to dark yellow
Storage Condition	2-8°C
In vitro study	BMH-21 causes proteasome-dependent destruction of RPA194, the large catalytic subunit protein of Pol I holocomplex. In U2OS cancer cell line, BMH-21 results in degradation of RPA194 and translocation of NCL with IC50 of 0.05 μM and 0.07 μM, respectively. By causing nucleolar stress, BMH-21 also shows potent inhibition on cell viability.
In vivo study	BMH-21 reduces tumor growth in mouse xenografts.

Hazard Symbols	Xn - Harmful
Risk Codes	22 - Harmful if swallowed

Last Update：2024-01-02 23:10:35

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Product Name: BMH21 Request for quotation
CAS: 896705-16-1
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052

Wechat: 15671228036

Spot supply

Product Name: BMH-21 Visit Supplier Webpage Request for quotation
CAS: 896705-16-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

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12H-Benzo[g]pyrido[2,1-b]quinazoline-4-carboxamide, N-[2-(dimethylamino)ethyl]-12-oxo- Request for Quotation